HCID 3468283, compound → HCID 20154242, compound

Participants

Reaction Steps

To a solution of 5.4 g of 3,4,5-trimethoxybenzoate in 100 ml of chloroform is added 4.0 g of 2-amino-4-(5-aminomethyl-2-thienyl)thiazole under cooling with ice at -5° C. to 0° C., and stirred at 15° C. to 25° C. for 4 hours. After the resulting mixture is cooled with ice, the precipitated crystals are collected by filtration and recrystallized from methanol to give 2-amino-4-[5-(3,4,5-trimethoxybenzoylaminomethyl)-2-thienyl]thiazole, melting at 217° C. with decomposition.

Provenance & Evidence