Ethyl formate → HCID 13983420, compound

Participants

Reaction Steps

The procedure is analogous to that described in Example 11 below, but starting with sodium (2.3 g), 4-fluoroacetophenone (13.8 g) and ethyl formate (11 g). The solid obtained (17.8 g) is then added to 2,6-diaminopyridine (11 g). The product obtained after hydrolysis and neutralization with sodium hydroxide is separated by filtration, washed with distilled water (6×100 cc) and air-dried. 2-Amino-7-(4-fluorophenyl)-1,8-naphthyridine (17.8 g), m.p. 175° C., is thus obtained.

Provenance & Evidence