Hydrochloric Acid → HCID 13983421, compound

Participants

Reaction Steps

The procedure is analgous to that described in Example 11, but starting with sodium (2.3 g), 2-chloroacetophenone (15 g) and ethyl formate (11 g). The solid obtained (20 g) is then added to 2,6-diaminopyridine (11 g). The product obtained after hydrolysis and neutralization with sodium hydroxide (21.5 g; m.p. approximately 165° C.) is dissolved in concentrated hydrochloric acid (d=1.19; 100 cc). The precipitate obtained after hydrolysis with distilled water (500 cc) is separated by filtration, washed with 0.5M sodium hydroxide (3×100 cc) followed by distilled water (5×50 cc) and air-dried. 2-Amino-7-(2-chlorophenyl)naphthyridine (11 g), m.p. 193° C., is obtained.

Provenance & Evidence