P-Chloroacetophenone → HCID 13983422, compound

Participants

Reaction Steps

The procedure is analogous to that described in Example 11, but starting with sodium (2.3 g), 4-chloroacetophenone (15.5 g) and ethyl formate (11 g). The solid obtained (20.4 g) is then added to 2,6-diaminopyridine (11.6 g). The product obtained after hydrolysis and neutralization with sodium hydroxide is separated by filtration, washed with distilled water (6×100 cc) at a temperature in the vicinity of 50° C., and then air-dried. 2-Amino-7-(4-chlorophenyl)-1,8-naphthyridine (22.6 g), m.p. approximately 130° C., is thus obtained.

Provenance & Evidence