Ethanol → HCID 13787376, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 2-amino-7-chloro-1,8-naphthyridine (9 g) in aniline (19.6 g) is heated for 19 hours at 120° C. The suspension obtained is filtered, washed with diethyl ether (3×15 cc) and air-dried. The crude solid obtained (14 g; m.p. 190° C.) is then dissolved in boiling ethanol (700 cc). After cooling for 2 hours at 4° C., the crystallized product is separated by filtration, washed with ethanol (25 cc) and air-dried. 2-Amino-7-anilino-1,8-naphthyridine (7.2 g), m.p. approximately 250° C., is obtained.

Provenance & Evidence