3-Bromobenzoic acid → HCID 20154392, compound

Participants

Reaction Conditions

Reaction Steps

The procedure is analogous to that described in Example 11, but starting with 3-bromobenzoic acid (2.8 g), N,N'-carbonyldiimidazole (2.3 g) and 2-amino-7-(3-fluorophenyl)-1,8-naphthyridine (2.4 g). The product obtained by precipitation in water (3.5 g; m.p. approximately 195° C.) is dissolved in a boiling mixture of dimethylformamide (20 cc) and acetonitrile (200 cc). After cooling for 4 hours at 4° C., the crystallized solid is separated by filtration, washed with acetonitrile (3×10 cc) and dried at 40° C. under reduced pressure (0.07 kPa). N-[7-(3-Fluorophenyl)-1,8-naphthyridin-2-yl]-3-bromobenzamide (2.3 g), m.p. 208° C., is obtained.

Provenance & Evidence