3-Chlorobenzoic Acid → HCID 20154403, compound

Participants

Reaction Conditions

Reaction Steps

The procedure is analogous to that described in Example 11, but starting with 3-chlorobenzoic acid (1.6 g), N,N'-carbonyldiimidazole (1.6 g) and 2-amino-7-(4-chlorophenyl)-1,8-naphthyridine (1.8 g). The product obtained by precipitation in water (2.2 g; m.p. approximately 190° C.) is dissolved in boiling propanol (400 cc). After cooling for 4 hours at 4° C., the crystallized solid is separated by filtration, washed with propanol (3×5 cc) and dried at 40° C. under reduced pressure (0.07 kPa). N-[7-(4-Chlorophenyl)-1,8-naphthyridin-2-yl]-3-chlorobenzamide (0.85 g), m.p. 222°-224° C., is obtained.

Provenance & Evidence