Methanol → HCID 20154401, compound

Participants

Reaction Conditions

Reaction Steps

The procedure is analogous to that described in Example 11, but starting with 3-bromobenzoic acid (1.6 g), N,N'-carbonyldiimidazole (1.3 g) and 2-amino(2-methoxyphenyl)-1,8-naphthyridine (1.3 g). The product obtained by precipitation in water (1.5 g) is dissolved in boiling methanol (75 cc). After cooling for 2 hours at 4° C., the crystallized solid is separated by filtration, washed with methanol (3×3 cc) and dried at 35° C. under reduced pressure (0.07 kPa). N-[7-(2-Methoxyphenyl)-1,8-naphthyridin-2-yl]-3-bromobenzamide (0.6 g), m.p. 110° C., is obtained.

Provenance & Evidence