Acetonitrile → HCID 20154410, compound

Participants

Reaction Conditions

Reaction Steps

The procedure is analogous to that described in Example 11, but starting with 3-bromobenzoic acid (2.8 g), N,N'-carbonyldiimidazole (2.3 g) and 2-amino-7-(3-methylphenyl)-1,8-naphthyridine (2.4 g). The product obtained by precipitation in water (2.3 g) is dissolved in boiling acetonitrile (300 cc). After 4 hours of cooling at 4° C., the crystallized solid is separated by filtration, washed with acetonitrile (3×5 cc) and dried at 35° C. under reduced pressure (0.07 kPa). N-[7-(3-Methylphenyl)-1,8-naphthyridin-2-yl]-3-bromobenzamide (1 g), m.p. 100° C., is obtained.

Provenance & Evidence