Ethyl formate → HCID 13983428, compound

Participants

Reaction Steps

The procedure is analogous to that described in Example 11, but starting with sodium (2.3 g), 3-methylacetophenone (13.4 g) and ethyl formate (11 g). The solid obtained (18.4 g) is then added to 2,6-diaminopyridine (12.1 g). The product obtained after hydrolysis and neutralization with sodium hydroxide (14 g); m.p. approximately 140° C.) is dissolved in concentrated hydrochloric acid (d=1.19; 100 cc). The precipitate obtained after hydrolysis with distilled water (500 cc) followed by neutralization with 10N sodium hydroxide is separated by filtration, washed with distilled water (5×50 cc) and methanol (2×50 cc), and then air-dried. 2-Amino-7-(3-methylphenyl)-1,8-naphthyridine (7.3 g), m.p. 180° C., is obtained.

Provenance & Evidence