HCID 54137321, compound → HCID 20154345, compound

Participants

Reaction Steps

24.62 g (0.07 mole) of 8-chloro-9-fluoro-5-ethyl-6,7-dihydro-1,7-dioxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid ethyl ester was suspended in a mixture of 50 ml of concentrated hydrochloric acid and 200 ml of acetic acid, and this suspension was stirred at 110°-120° C. for 3 hours to hydrolyze the starting material. The resulting reaction solution was allowed to cool to room temperature. The precipitate which separated out was collected by filtration and washed with water to obtain 16.95 g (74.8% yield) of 8-chloro-9-fluoro-5-ethyl-6,7-dihydro-1,7-dioxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid in the form of pale-yellow crystals.

Provenance & Evidence