Acetic Acid → HCID 13960207, compound

Participants

Reaction Steps

3.87 g (0.01 mole) of 9-fluoro-5-methyl-8-(1-piperazinyl)-6,7-dihydro-1,7-dioxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid ethyl ester was suspended in 12 ml of ethanol, 50 ml of a 2N aqueous solution of sodium hydroxide was added thereto, and this mixture was stirred at 20°-25° C. for 2 hours to hydrolyze the starting material. The resulting reaction solution was adjusted to pH 4-5 by the addition of acetic acid under cooling with ice. The precipitate which separated out was collected by filtration and recrystallized from ethanol to obtain 2.91 g (81.0% yield) of 9-fluoro-5-methyl-8-(1-piperazinyl)-6,7-dihydro-1,7-dioxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid in the form of yellow crystals. These crystals had a melting point of 261°-263° C. (dec.).

Provenance & Evidence