Sodium Hydroxide → HCID 230241, compound

HRID 2414050Notes

Reaction equation

HRID 2414050 reaction equation
Cl.[Cl:2][CH2:3][CH2:4][NH2:5].[OH-].[Na+].[C:8]1([O:14][C:15](Cl)=[O:16])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>C(Cl)Cl>[Cl:2][CH2:3][CH2:4][NH:5][C:15](=[O:16])[O:14][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

5

Reactant 3

HCID 14798Sodium Hydroxide2×HCID 15891Phenyl chloroformateHCID 97937372-Chloroethylamine hydrochloride

Product 1

HCID 230241HCID 230241, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1500 ml of an aqueous solution of 696 g (6 moles) of 2-chloroethylamine hydrochloride and 1500 g of sodium hydroxide solution containing 480 g (12 moles) of sodium hydroxide are simultaneously added dropwise to a solution of 936 (6 moles) of phenylchloroformate in 3 l of methylene chloride at 15° to 20° C. The mixture is worked up as described under Example 7 to give 1161 g of O-phenyl N-(2-chloroethyl)-carbamate of melting point 65° to 67° C.; purity according to gas chromatography: 95.7% (93% of theory).

Sources & evidence

ORD record
ord-aa980578ae3945c89feab3f0d80dae3c
Source dataset
uspto-grants-1988_01
Patent number
US04721523

Reaction notes

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