Benzene → Acetophenone

HRID 2414052Notes

Reaction equation

HRID 2414052 reaction equation
[CH:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:7](Cl)(=[O:9])[CH3:8]>[O-]S(C(F)(F)F)(=O)=O.[Ga+3].[O-]S(C(F)(F)F)(=O)=O.[O-]S(C(F)(F)F)(=O)=O>[C:7]([C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)(=[O:9])[CH3:8]

Participants

4

Reactant 2

HCID 241BenzeneHCID 6367Acetyl chloride

Product 1

HCID 7410Acetophenone

Reagents, catalysts & solvents 1

HCID 2733940GALLIUM(III) TRIFLUOROMETHANESULFONATECatalyst

Procedure

Benzene (1 equivalent) was reacted with acetyl chloride (0.5 equivalents) in the presence of 0.25 equivalents of gallium triflate catalyst at 50°-60° C. for 1 hour giving 0.35 equivalents of acetophenone.

Sources & evidence

ORD record
ord-ce1ac4ec6d65456b835cf9d043870e9a
Source dataset
uspto-grants-1988_01
Patent number
US04721559

Reaction notes

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