Propargyl bromide → HCID 20153800, compound

Participants

Reaction Steps

4-Methyl-6-phenyl-3-(prop-2-ynylamino)-pyridazine is prepared by heating 7 g of 3-amino-4-methyl-6-phenyl-pyridazinium and 9 ml of propargyl bromide at 60° C. for 2 hours. After evaporation of the excess propargyl bromide, the residue is taken up in 300 ml of anhydrous benzene, and 1.77 g of sodium are added. The mixture is heated under reflux for 15 hours and the solution is then poured into excess solid carbon dioxide and left in contact therewith for several hours.

Provenance & Evidence