Tetrahydrofuran → HCID 53851550, compound

Participants

Reaction Conditions

Reaction Steps

To the solution of 36.75 g of 4-diisopropylamino 2-(2-pyridyl butyronitrile (Example 1a) in 300 ml of tetrahydrofuran are added at ambient temperature 71.7 g of Triton B then 15.9 g of 1-cyclohexene carbonitrile dissolved in 100 ml of tetrahydrofuran. The mixture is left for one night with stirring at ambient temperature (about 20° C.), then the solvent is evaporated to dryness. The residue is taken up in water and extracted 3 times with ether. The solvent is evaporated and the residue is chromatographed over a column of alumina. By eluting with a pentane-ethyl acetate (80-20) vol/vol mixture, 20 g of the expected product are obtained, used as such for cyclization.

Provenance & Evidence