Hydrochloric Acid → HCID 50923465, compound

Participants

Reaction Steps

5 ml of 4M HCl in dioxane are added to 41.8 mg (0.091 mmol) of tert-butyl 4-{4-[6-amino-5-(1H-benzimidazol-2-yl)pyridin-3-yl]pyrazol-1-yl}piperidine-1-carboxylate, and the mixture is stirred at room temperature for 14 h. The reaction mixture is evaporated to dryness, and water is added. The aqueous phase is adjusted to pH>10 using 2N NaOH and extracted 3× with ethyl acetate. The organic phases are dried using sodium sulfate, filtered and evaporated. The residue is lyophilised, giving 3-(1H-benzimidazol-2-yl)-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-ylamine as free base; HPLC-MS [M+H]+ 360.2;

Provenance & Evidence