Thioacetamide → 6-(2,5-Dimethyl-4-thiazolyl)-3,4-dihydro-2(1H)-quinolinone

Participants

Reaction Steps

A mixture of 6-(α-bromopropionyl)-3,4-dihydrocarbostyril (7 g), thioacetamide (2 g) and absolute ethanol (250 ml) is stirred under reflux for 3 hours and allowed to cool overnight. The resulting white precipitate is filtered, washed with ether, dried and suspended in aqueous sodium bicarbonate for 30 minutes. The neutralized solid is filtered, washed with water, isopropanol, and recrystallized from isopropanol affording the desired product, M.P. 241°-242° C.

Provenance & Evidence