HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thiourea → 5-(2-Amino-4-thiazolyl)-1,3-dihydro-2H-indol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thiourea | HCID 2723790 | — |
| Reactant | 5-(Bromoacetyl)-1,3-dihydro-2H-indol-2-one | HCID 22099309 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-(2-Amino-4-thiazolyl)-1,3-dihydro-2H-indol-2-one | HCID 2608761 | — |
Reaction Steps
A solution of 5-(α-bromoacetyl)oxindole (5 g) and thiourea (1.67 g) in absolute EtOH (250 ml) is refluxed for 30 minutes. The reaction mixture is cooled to RT, filtered, and washed with absolute EtOH affording the desired product. The free base is converted to its methanesulfonate salt by the procedure previously described in Example 12, affording the desired product, M.P.=244°-246° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04721721 |
| Source dataset | uspto-grants-1988_01 |
| ORD ID | ord-3b586d910641479c91ccb9d565a2c5aa |
| Source note | uspto-grants-1988_01 |