1-Azabicyclo[2.2.2]octane-4-carbonitrile → 1-Azabicyclo[2.2.2]octane-4-carbonitrile, 4-methylbenzenesulfonate (1:1)

Participants

Reaction Conditions

Reaction Steps

4-Cyanoquinuclidine (85.0 g) was suspended in ethanol (200 ml), followed by an addition of a solution of p-toluenesulfonic acid monohydrate (119 g) in ethanol (350 ml). The resulting mixture was then stirred at 40° C. for 1 hour. The reaction mixture was cooled with ice and the precipitated crystals were collected by filtration. They were then washed with ethanol and diethylether to obtain 182.9 g of 4-cyanoquinuclidine p-toluenesulfonate as colorless crystals (yield: 95%).

Provenance & Evidence