Sodium Hydroxide → HCID 178508431, compound

Participants

Reaction Steps

9.2 51 mg (0.121 mmol) of ethyl [2-(2-amino-5-iodopyridin-3-yl)-1H-benzimidazol-5-yl]acetate are dissolved in 5 ml of methanol, and 242 μl of 1N NaOH (0.242 mmol) are added. The reaction mixture is irradiated for 10 min at 100° C. in a microwave unit. After cooling, it is evaporated to dryness and adjusted to pH 4-5 by means of 1N HCl. The precipitate formed is filtered off with suction and dried, giving [2-(2-amino-5-iodopyridin-3-yl)-1H-benzimidazol-5-yl]acetic acid; HPLC-MS [M+H]+ 395.0.

Provenance & Evidence