1,2-Dichloroethane → HCID 67494571, compound

Participants

Reaction Steps

14.2 157 mg (0.111 mmol) of 5-[6-amino-5-(6-methoxy-1H-benzimidazol-2-yl)pyridin-3-yl]thiophene-2-carboxylic acid are dissolved in 0.5 ml of DMF. 10 μl (0.114 mmol) of 2-methoxyethylamine, 14.9 mg (0.111 mmol) of HOBt, 21.2 mg (0.111 mmol) of EDC and 24.3 μl (0.221 mmol) of N-methylmorpholine are added. The reaction mixture is stirred at room temperature for 14 h, water is added, and the mixture is extracted with ethyl acetate. The organic phases are dried using sodium sulfate, filtered and evaporated. The residue is purified by means of RP-HPLC and lyophilised, giving N-(2-methoxyethyl)-5-[6-amino-5-(6-methoxy-1H-benzimidazol-2-yl)pyridin-3-yl]-thiophene-2-carboxamide; HPLC-MS [M+H]+ 424.2.

Provenance & Evidence