Triethylamine → HCID 67494921, compound

Participants

Reaction Steps

480 mg (2.649 mmol) of 4-(2-aminoethyl)-2-nitrophenylamine are dissolved in 30 ml of dioxane, and 1.102 ml (7.950 mmol) of triethylamine are added. 0.334 ml (2.650 mmol) of 3,4-difluorobenzoyl chloride are then added dropwise, and the mixture is stirred at room temperature for 30 min. Ethyl acetate is added to the reaction mixture, which is then washed 3× with water, dried using sodium sulfate, filtered and distilled off to dryness, giving N-[2-(4-amino-3-nitrophenyl)ethyl]-3,4-difluorobenzamide; EI-MS [M]+ 321, which is hydrogenated further under standard conditions, giving N-[2-(3,4-diaminophenyl)ethyl]-3,4-difluorobenzamide; HPLC-MS [M+H]+ 292.2.

Provenance & Evidence