Bromotrimethylsilane → HCID 22644540, compound

HRID 2414235Notes

Reaction equation

HRID 2414235 reaction equation
C[Si](Br)(C)C.C[O:7][P:8]([C:12](=[O:17])[CH2:13][CH2:14][NH:15][OH:16])(=[O:11])[O:9]C>C(#N)C>[OH:16][NH:15][CH2:14][CH2:13][C:12]([P:8](=[O:7])([OH:11])[OH:9])=[O:17]

Participants

4

Reactant 2

HCID 76113BromotrimethylsilaneHCID 57225330HCID 57225330, compound

Product 1

HCID 22644540HCID 22644540, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

0,2 mol trimethylsilylbromide are slowly added to a solution of 0,1 mol 3-(N-hydroxyamino)-propionylphosphonic acid dimethylester in 100 ml of absolute acetonitrile. After 3 hours of stirring at room temperature the solution is concentrated and taken up in 50 ml methanol. After stirring for 30 minutes it is concentrated again. 3-(N-hydroxyamino)-propionylphosphonic acid may be further be converted without purification.

Workup

  1. concentrationis concentrated
  2. stirringAfter stirring for 30 minutes it
  3. concentrationis concentrated again
  4. custom3-(N-hydroxyamino)-propionylphosphonic acid may be further be converted without purification

Sources & evidence

ORD record
ord-8d68706a10a049649cb2e2fccfcaa43d
Source dataset
uspto-grants-2004_11
Patent number
US06812224B2

Reaction notes

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