2,4,6-Trimethylpyridine → HCID 22644528, compound

Participants

Reaction Conditions

Reaction Steps

With reference to K -L. Yu, J. J.Bronson, H.Yang, A.Patick, M.Alam, V.Brankovan, R.Datema, M. J. M.Hitchcock, J. C.Martin, J. Med. Chem. 1992, 35, 2958-2969 0.5 mol [2-(N-hydroxyamino)-ethoxy]methylphosphonic acid diethylester and 1 mol 2,4,6-collidine in 5 ml of absolute methylenechloride are stirred under argon for one hour at a temperature of 0° C. After allowing to stand for 16 hours at room temperature the-solution is concentrated in vacuum, taken up in watery acetone and stirred for 14 hours. Subsequently it is taken up in 1 n NaOH and heated to 100° C. for 2 h. After cooling-off it is concentrated and the raw product purified by chromatography.

Provenance & Evidence