HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formic Acid → N-[2-(3-Methoxyphenyl)ethyl]formamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formic Acid | HCID 284 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | 3-Methoxyphenethylamine | HCID 74866 | — |
| Product | N-[2-(3-Methoxyphenyl)ethyl]formamide | HCID 13562936 | 73% |
Reaction Steps
A solution of 2-(3-methoxy-phenyl)-ethylamine (50.0 g, 0.33 mol) in formic acid (60 mL) was refluxed overnight. Water (250 mL) was added and the emulsion extracted with ethyl acetate (2×150 mL). The organic layer was separated, dried (Na2SO4) and concentrated to give N-[2-(3-methoxy-phenyl)-ethyl]-formamide (43.1 g, 73%). MS: 180.1 (M+1+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06812228B2 |
| Source dataset | uspto-grants-2004_11 |
| ORD ID | ord-476a4d289ee3450f97da8411475f63db |
| Source note | uspto-grants-2004_11 |