14446-29-8 → HCID 10203251, compound

HRID 2414251Notes

Reaction equation

HRID 2414251 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([OH:19])[C:13]=2[CH2:15][N:16]([CH3:18])[CH3:17])[N:8]([CH3:20])[C:7]=1[CH2:21][CH2:22][CH3:23])=[O:5])[CH3:2].[CH3:24][O:25][C:26]1[CH:27]=[C:28]2[C:33](=[CH:34][CH:35]=1)C=NC[CH2:29]2>>[CH2:1]([O:3][C:4]([C:6]1[C:14]2=[C:13]3[C:12](=[CH:11][CH:10]=[C:9]2[N:8]([CH3:20])[C:7]=1[CH2:21][CH2:22][CH3:23])[O:19][CH:17]1[N:16]([CH2:18][CH2:29][C:28]2[CH:27]=[C:26]([O:25][CH3:24])[CH:35]=[CH:34][C:33]=21)[CH2:15]3)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 1001219614446-29-8HCID 11726900HCID 11726900, compound

Product 1

HCID 10203251HCID 10203251, compoundYield 8%

Procedure

By following the general procedure of Example 2 for the preparation of 9-methoxy-2-propyl-11,12-dihydro-3H,6αH,13H-6-oxa-3,12α-diaza-benzo[a]cyclopent[h]anthracene-1-carboxylic acid ethyl ester, 4-(dimethylamino-methyl)-5-hydroxy-1-methyl-2-propyl-1H-indole-3-carboxylic acid ethyl ester (2.1 g, 6.6 mmol) was reacted with 6-methoxy-3,4-dihydro-isoquinoline (1.005 g, 6.6 mmol) to give the desired product (0.22 g, 8%). MP 150-151° C. MS: 435.2 (M+1+).

Sources & evidence

ORD record
ord-abacda32d72345daad9c6ac9a594fd17
Source dataset
uspto-grants-2004_11
Patent number
US06812228B2

Reaction notes

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