4-Chloro-N-isopropyl-3-nitrobenzenesulfonamide → n-(1-Methylethyl)-3-nitro-4-[4-(2-oxo-2h-3,1-benzoxazin-1(4h)-yl)piperidin-1-yl]benzenesulfonamide

HRID 2414317Notes

Reaction equation

HRID 2414317 reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][CH:12]([CH3:14])[CH3:13])(=[O:10])=[O:9])=[CH:4][C:3]=1[N+:15]([O-:17])=[O:16].Cl.[NH:19]1[CH2:24][CH2:23][CH:22]([N:25]2[C:30]3[CH:31]=[CH:32][CH:33]=[CH:34][C:29]=3[CH2:28][O:27][C:26]2=[O:35])[CH2:21][CH2:20]1>>[CH3:13][CH:12]([NH:11][S:8]([C:5]1[CH:6]=[CH:7][C:2]([N:19]2[CH2:20][CH2:21][CH:22]([N:25]3[C:30]4[CH:31]=[CH:32][CH:33]=[CH:34][C:29]=4[CH2:28][O:27][C:26]3=[O:35])[CH2:23][CH2:24]2)=[C:3]([N+:15]([O-:17])=[O:16])[CH:4]=1)(=[O:10])=[O:9])[CH3:14]

Participants

3

Reactant 2

HCID 667804-Chloro-N-isopropyl-3-nitrobenzenesulfonamideHCID 220630891-(4-Piperidinyl)-1,2-dihydro-4H-3,1-benzoxazin-2-one hydrochloride

Product 1

HCID 22644650n-(1-Methylethyl)-3-nitro-4-[4-(2-oxo-2h-3,1-benzoxazin-1(4h)-yl)piperidin-1-yl]benzenesulfonamide

Procedure

The title compound was prepared from the product of step (i) (0.14 g) and 1-piperidin-4-yl-1,4-dihydro-2H-3,1-benzoxazin-2-one hydrochloride (0.1 g) using the method of example 115 step (ii). Yield 0.037 g.

Sources & evidence

ORD record
ord-504d5cbb68fb495eaaeaf3d25c60df79
Source dataset
uspto-grants-2004_11
Patent number
US06812226B2

Reaction notes

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