HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-1-fluoro-4-nitrobenzene → 1-[1-(2-Chloro-4-nitrophenyl)piperidin-4-yl]-1,4-dihydro-2h-3,1-benzoxazin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-1-fluoro-4-nitrobenzene | HCID 67688 | — |
| Reactant | 1-(4-Piperidinyl)-1,2-dihydro-4H-3,1-benzoxazin-2-one hydrochloride | HCID 22063089 | — |
| Product | 1-[1-(2-Chloro-4-nitrophenyl)piperidin-4-yl]-1,4-dihydro-2h-3,1-benzoxazin-2-one | HCID 22644572 | — |
Reaction Steps
The product was prepared from 1-piperidin-4yl-1,4-dihydro-2H-3,1-benzoxazin-2-one hydrochloride (1.5 g) and 3-chloro-4-fluoronitrobenzene (1.23 g) using the method of example 115 step (ii). Yield 1.37 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06812226B2 |
| Source dataset | uspto-grants-2004_11 |
| ORD ID | ord-bf4d5c53bea0423f88be33002bfd1704 |
| Source note | uspto-grants-2004_11 |