反应详情

Isobutyryl chloride (0.017 ml) was added to a stirred solution of the product from example 120 step (ii) (0.05 g) and triethylamine (0.07 ml) in dichloromethane (1 ml) at room temperature. After 2 h the mixture was partitioned between ethyl acetate and water, the organics separated, washed with water, dried, and evaporated under reduced pressure. Trituration with ether gave a solid, yield 0.048 g.

1. customAfter 2 h the mixture was partitioned between ethyl acetate and water
2. washthe organics separated, washed with water
3. customdried
4. customevaporated under reduced pressure
5. customTrituration with ether gave a solid, yield 0.048 g