2-Aminobenzyl alcohol → HCID 22644602, compound

HRID 2414331Notes

Reaction equation

HRID 2414331 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11](=O)[CH:10]([CH3:15])[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH2:16][C:17]1[CH:24]=[CH:23][CH:22]=[CH:21][C:18]=1[CH2:19][OH:20]>>[OH:20][CH2:19][C:18]1[CH:21]=[CH:22][CH:23]=[CH:24][C:17]=1[NH:16][CH:11]1[CH2:12][CH2:13][N:8]([C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:7])[CH2:9][CH:10]1[CH3:15]

Participants

3

Reactant 2

HCID 214392-Aminobenzyl alcoholHCID 22644642tert-Butyl 3-methyl-4-oxopiperidine-1-carboxylate

Product 1

HCID 22644602HCID 22644602, compound

Procedure

The product was prepared from N-tert-butoxycarbonyl-3-methyl-4-piperidone (4.3 g) and 2-amino-benzyl alcohol (2.59 g) using the method of example 7 step (i). Yield 6.3 g as a mixture of diastereoisomers.

Workup

  1. additionYield 6.3 g as a mixture of diastereoisomers

Sources & evidence

ORD record
ord-88fbe39f58254c89b858168bf42fa440
Source dataset
uspto-grants-2004_11
Patent number
US06812226B2

Reaction notes

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