HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylic Acid → 2-[4-(2-Oxo-2h-3,1-benzoxazin-1(4h)-yl)piperidin-1-yl]-4-(trifluoromethyl)pyrimidine-5-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylic Acid | HCID 10823150 | — |
| Reactant | 1-(4-Piperidinyl)-1,2-dihydro-4H-3,1-benzoxazin-2-one hydrochloride | HCID 22063089 | — |
| Product | 2-[4-(2-Oxo-2h-3,1-benzoxazin-1(4h)-yl)piperidin-1-yl]-4-(trifluoromethyl)pyrimidine-5-carboxylic acid | HCID 22644596 | — |
Reaction Steps
The title compound was prepared from 1-piperidin-4-yl-1,4-dihydro-2H-3,1-benzoxazin-2-one hydrochloride (0.70 g) and 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylic acid (1.8 g) using the method of example 115 step (ii). Yield 1.1 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06812226B2 |
| Source dataset | uspto-grants-2004_11 |
| ORD ID | ord-d8e8f080c7fa428a8799b33f6706aba9 |
| Source note | uspto-grants-2004_11 |