Leucinamide hydrochloride → HCID 59042572, compound

HRID 2414341Notes

Reaction equation

HRID 2414341 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:25]([OH:27])=O)[CH:5]=[N:6][C:7]=1[N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=3[CH2:17][O:16][C:15]2=[O:24])[CH2:10][CH2:9]1.Cl.[NH2:29][C@H:30]([C:35]([NH2:37])=[O:36])[CH2:31][CH:32]([CH3:34])[CH3:33]>>[NH2:37][C:35]([C@@H:30]([NH:29][C:25]([C:4]1[CH:5]=[N:6][C:7]([N:8]2[CH2:13][CH2:12][CH:11]([N:14]3[C:19]4[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=4[CH2:17][O:16][C:15]3=[O:24])[CH2:10][CH2:9]2)=[C:2]([Cl:1])[CH:3]=1)=[O:27])[CH2:31][CH:32]([CH3:34])[CH3:33])=[O:36]

Participants

3

Reactant 2

HCID 2733199Leucinamide hydrochlorideHCID 226445845-Chloro-6-[4-(2-oxo-2h-3,1-benzoxazin-1(4h)-yl)piperidin-1-yl]pyridine-3-carboxylic acid

Product 1

HCID 59042572HCID 59042572, compound

Procedure

The title compound was prepared from the product of example 148 step (i) (0.15 g) and (S)-leucinamide hydrochloride (0.07 g) according to the method of example 115, step (i). Yield 0.04 g as a solid.

Sources & evidence

ORD record
ord-7e2f50bc3c2e437892f8c458e565e3f2
Source dataset
uspto-grants-2004_11
Patent number
US06812226B2

Reaction notes

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