Sodium Nitrite → HCID 22644641, compound

Participants

Reaction Steps

A solution of sodium nitrite (0.11 g) in water (1 ml) was added to a stirred solution of the product from example 159 step (ii) (0.456 g) in acetonitrile (10 ml) at room temperature. After 1 h a solution of iron sulphate (0.3 g) in N,N-dimethylformamide (20 ml) was added and the mixture stirred for a further 30 min. The mixture was partitioned between ethyl acetate and water, the organics dried and evaporated under reduced pressure. Purification was by chromatography eluting with 20% ethyl acetate/isohexane. Yield 0.29 g as an oil.

Provenance & Evidence