Leucinamide hydrochloride → HCID 59042569, compound

HRID 2414346Notes

Reaction equation

HRID 2414346 reaction equation
[O:1]=[C:2]1[O:7][CH2:6][C:5]2[CH:8]=[CH:9][CH:10]=[CH:11][C:4]=2[N:3]1[CH:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:30]=[CH:29][C:21]([C:22](OC(C)(C)C)=[O:23])=[CH:20][CH:19]=2)[CH2:14][CH2:13]1.Cl.[NH2:32][C@H:33]([C:38]([NH2:40])=[O:39])[CH2:34][CH:35]([CH3:37])[CH3:36]>>[NH2:40][C:38]([C@@H:33]([NH:32][C:22](=[O:23])[C:21]1[CH:29]=[CH:30][C:18]([N:15]2[CH2:16][CH2:17][CH:12]([N:3]3[C:4]4[CH:11]=[CH:10][CH:9]=[CH:8][C:5]=4[CH2:6][O:7][C:2]3=[O:1])[CH2:13][CH2:14]2)=[CH:19][CH:20]=1)[CH2:34][CH:35]([CH3:37])[CH3:36])=[O:39]

Participants

3

Reactant 2

HCID 2733199Leucinamide hydrochlorideHCID 22644641HCID 22644641, compound

Product 1

HCID 59042569HCID 59042569, compound

Procedure

The title compound was prepared from the product of example 161 step (i) (0.06 g) and (S)-leucinamide hydrochloride (0.056 g) using the method of example 161 step (ii). Purification was by chromatography eluting with (5:1) ethyl acetate/dichloromethane. Yield 0.01 g as a solid.

Workup

  1. customPurification
  2. washeluting with (5:1) ethyl acetate/dichloromethane

Sources & evidence

ORD record
ord-ce42c2e6776a4ae5a033858046f586e4
Source dataset
uspto-grants-2004_11
Patent number
US06812226B2

Reaction notes

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