HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 12132659, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | HCID 10523682 | HCID 10523682 | — |
| Reactant | 4-(Dimethylamino)butyric acid hydrochloride | HCID 12691640 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 12132659 | HCID 12132659 | 60% |
Reaction Steps
To a solution of 7-(acetoxymethyl)-5-amino-2-[4-amino-3-fluorophenyl]-6,8-difluoro-4H-1-benzopyran-4-one (500 mg, 1.32 mmol) in dimethylformamide (15 mL) were added 4-dimethylaminobutyric acid hydrochloride (3.06 g, 16.9 mmol) and 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride (3.23 g, 16.9 mmol), and the mixture was stirred at room temperature for 2.5 hours. Water was added thereto, and the mixture was extracted with ethyl acetate. Purification by silica gel column chromatography (9:1 chloroform/methanol) gave 1j (386 mg, 60%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06812246B2 |
| Source dataset | uspto-grants-2004_11 |
| ORD ID | ord-1b424885fcff4808936d5de14ae63791 |
| Source note | uspto-grants-2004_11 |