Pyridine → HCID 86589055, compound

Participants

Reaction Steps

To a solution of pyridine (0.78 mL, 9.7 mmol) in CH2Cl2 (50 mL) at −10° C. is added triflic anhydride (1.68 mL, 10.0 mmol) over 15 min. A solution of benzyl (R)-2-hydroxy-3-(3-methylphenyl)-propionate (1.5 g, 5.55 mmol) in CH2Cl2 (15 mL) is then added dropwise over 30 min., and the mixture is warmed to room temp. over 1 h. The solution is diluted with CH2Cl2 (100 mL), washed with water (2×100 mL) and brine (100 mL), dried (MgSO4), and evaporated to yield benzyl (R)-2-trifluoromethanesulfonyloxy-3-(3-methylphenyl)-propionate as a yellowish oil.

Provenance & Evidence