HCID 86589056, compound → HCID 59089134, compound

HRID 2414384Notes

Reaction equation

HRID 2414384 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:6]=[C:7]([NH:11][C@@H:12]([CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([CH3:30])[CH:25]=2)[C:13]([O:15]CC2C=CC=CC=2)=[O:14])[CH:8]=[CH:9][CH:10]=1)=[O:4]>CCO.[Pd]>[CH3:1][O:2][C:3]([C:5]1[CH:6]=[C:7]([NH:11][C@@H:12]([CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([CH3:30])[CH:25]=2)[C:13]([OH:15])=[O:14])[CH:8]=[CH:9][CH:10]=1)=[O:4]

Participants

4

Reactant 1

HCID 86589056HCID 86589056, compound

Product 1

HCID 59089134HCID 59089134, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of benzyl (S)-2-(3-methoxycarbonylphenylamino)-3-(3-methylphenyl)-propionate (0.25 g, 0.62 mmol) and 10% Pd/C (0.25 g) in EtOH (25 mL) is hydrogenated at 1 atm for 1 h. The mixture is filtered through celite and evaporated to yield (S)-2-(3-methoxycarbonylphenylamino)-3-(3-methylphenyl)-propionic acid, as a grey oil.

Workup

  1. filtrationThe mixture is filtered through celite
  2. customevaporated

Sources & evidence

ORD record
ord-9b9b28f9bb554202b29dbf6a934b01b9
Source dataset
uspto-grants-2004_11
Patent number
US06812237B2

Reaction notes

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