HCID 23533837, compound → HCID 12148457, compound

Participants

Reaction Steps

N-[2-[3-(allyloxycarbonyl)-benzyloxy]-1(S)-cyanoethyl]-3-methyl-Nα-(t-butoxycarbonyl)-L-phenylalaninamide (4.36 g, 8.37 mmol) in formic acid (47 mL) is stirred at room temp. for 6 h, after which time the formic acid is evaporated at 25° C. The residue is then dissolved in water (50 mL), basified with sat'd aqueous NaHCO3, and extracted with ethyl acetate (3×50 mL). The combined organic layers are then washed with water (50 mL), brine (50 mL), dried (MgSO4) and evaporated to yield N-[2-[3-(allyloxycarbonyl)-benzyloxy]-1(S)-cyanoethyl]-3-methyl-L-phenylalaninamide, as a clear oil, which is utilized without further purification.

Provenance & Evidence