Sodium Hydroxide → 4-{[1-(tert-Butoxycarbonyl)piperidin-4-yl]oxy}benzoic acid

Participants

Reaction Steps

847 mg (2.43 mmol) of ethyl 4-(1-t-butoxycarbonyl-4-piperidyloxy)benzoate was dissolved in 50 ml of ethanol. 5 ml of 1 N sodium hydroxide solution was added to the obtained solution, and they were stirred at room temperature for 3 days. The reaction solution was concentrated and then treated with ethyl acetate as the extraction solvent in an ordinary manner to obtain the title compound.

Provenance & Evidence