HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2414401Generated: November 1, 2026
Ethyl Acetate → t-Butyl [2-(5-cyano-2-iodophenoxy)ethyl]carbamate
https://huagongshe.com/reaction/2414401
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | tert-Butyl N-(2-bromoethyl)carbamate | HCID 4103526 | — |
| Reactant | 3-Hydroxy-4-iodobenzonitrile | HCID 10944681 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | t-Butyl [2-(5-cyano-2-iodophenoxy)ethyl]carbamate | HCID 11111864 | — |
Reaction Steps
18.5 g (82.6 mmol) of t-butyl (2-bromoethyl)carbamate was dissolved in 200 ml of DMF. 10.1 g (41.3 mmol) of 3-hydroxy-4-iodobenzonitrile and 5.7 g (41.3 mmol) of potassium carbonate were added to the obtained solution, and they were stirred at 75° C. for 3 hours. After the treatment with ethyl acetate as the extraction solvent in an ordinary manner, the title compound was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06812231B2 |
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| Source dataset | uspto-grants-2004_11 |
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| ORD ID | ord-044b816ee02f41e68502fdae46d90b00 |
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| Source note | uspto-grants-2004_11 |
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