HCID 22645937, compound → HCID 22645936, compound

Participants

Reaction Steps

Starting from the compound N-(4-oxochroman-2-ylmethyl)acetamide 1, the carbonyl group is hydrogenated to the hydroxyl group with noble-metal catalysis, for example using Pd on carbon (50% water-moist), to give the compound N-(4-hydroxychroman-2-ylmethyl)acetamide 2. The acetyl group is cleaved off using a base, for example sodium hydroxide. Addition of an acid gives the acid-addition salt 3 of 2-aminomethylchroman-4-ol. A further noble metal-catalysed hydrogenation generates the acid-addition salt 4 of 2-aminomethylchromane.

Provenance & Evidence