HCID 23533336, compound → HCID 23533335, compound

HRID 2414516Notes

Reaction equation

HRID 2414516 reaction equation
CN1CCN(C2C=CC3C(C=2)=CC=C2C=3OC(C(NC3C=CC([N:30]4[CH2:35][CH2:34][O:33][CH2:32][CH2:31]4)=CC=3)=O)=CC2=O)CC1.N1(C([C:46]2[CH:51]=[CH:50][C:49]([NH:52][C:53]([C:55]3[O:56][C:57]4[C:62]([C:63](=[O:65])[CH:64]=3)=[CH:61][CH:60]=[CH:59][C:58]=4[N:66]3[CH2:71][CH2:70][N:69]([CH3:72])[CH2:68][CH2:67]3)=[O:54])=[CH:48][CH:47]=2)=O)CCOCC1>>[N:30]1([C:51]2[CH:50]=[C:49]([NH:52][C:53]([C:55]3[O:56][C:57]4[C:62]([C:63](=[O:65])[CH:64]=3)=[CH:61][CH:60]=[CH:59][C:58]=4[N:66]3[CH2:67][CH2:68][N:69]([CH3:72])[CH2:70][CH2:71]3)=[O:54])[CH:48]=[CH:47][CH:46]=2)[CH2:35][CH2:34][O:33][CH2:32][CH2:31]1

Participants

3

Reactant 2

HCID 23533336HCID 23533336, compoundHCID 69272428HCID 69272428, compound

Product 1

HCID 23533335HCID 23533335, compound

Procedure

This compound was prepared from 8-(4-Methyl-piperazin-1-yl)-4-oxo-4H-chromene-2-carboxylic acid hydrochloride (Reference Example 1) and 3-morpholin-4-yl-phenylamine (Reference Example 18) as prepared in Example 12, yielding a yellow solid. (120 mg=86%), LCMS-m/z=449.5.

Workup

  1. customas prepared in Example 12
  2. customyielding a yellow solid

Sources & evidence

ORD record
ord-26d4e12f027b4661a78e46f50172505c
Source dataset
uspto-grants-2004_11
Patent number
US06812225B2

Reaction notes

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