3-Chloro-4-morpholinoaniline → 6-Methoxy-8-(4-Methyl-piperazin-1-yl)-4-oxo-4H-chromene-2-carboxylic acid (3-chloro-4-morpholin-4-yl-phenyl)-amide

Participants

Role	Name	HCID	Charge
Reactant	3-Chloro-4-morpholinoaniline	HCID 108661	—
Reactant	6-Methoxy-8-(4-Methyl-piperazin-1-yl)-4-oxo-4H-chromene-2-carboxylic acid hydrochloride	HCID 69266755	—
Product	6-Methoxy-8-(4-Methyl-piperazin-1-yl)-4-oxo-4H-chromene-2-carboxylic acid (3-chloro-4-morpholin-4-yl-phenyl)-amide	HCID 23533348	—

Reaction Steps

This compound was prepared from 6-Methoxy-8-(4-methyl-piperazin-1-yl)-4-oxo-4H-chromene-2-carboxylic acid hydrochloride (Reference Example 2) and commercially available 3-chloro-4-morpholin-4-yl-phenylamine (Maybridge) as prepared in Example 12, yielding a yellow solid. (45 mg=31%) LCMS-m/z=513.5.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06812225B2
Source dataset	uspto-grants-2004_11
ORD ID	ord-09c5262f4fc346ccb71245b285c001ff
Source note	uspto-grants-2004_11