2-Methoxy-4-morpholinoaniline → 6-Methoxy-8-(4-methyl-piperazin-1-yl)-4-oxo-4H-chromene-2-carboxylic acid (2-methoxy-4-morpholin-4-yl-phenyl)-amide

Participants

Role	Name	HCID	Charge
Reactant	2-Methoxy-4-morpholinoaniline	HCID 414960	—
Reactant	6-Methoxy-8-(4-Methyl-piperazin-1-yl)-4-oxo-4H-chromene-2-carboxylic acid hydrochloride	HCID 69266755	—
Product	6-Methoxy-8-(4-methyl-piperazin-1-yl)-4-oxo-4H-chromene-2-carboxylic acid (2-methoxy-4-morpholin-4-yl-phenyl)-amide	HCID 23533324	—

Reaction Steps

This compound was prepared from 6-methoxy-8-(4-Methyl-piperazin-1-yl)-4-oxo-4H-chromene-2-carboxylic acid hydrochloride (Reference Example 2) and commercially available 2-methoxy-4-morpholin-4-yl-phenylamine (SALOR) as prepared in Example 12, yielding a yellow solid. (55 mg=38%), LCMS-m/z=510.5.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06812225B2
Source dataset	uspto-grants-2004_11
ORD ID	ord-f9da706d5307413d9201840425dd0825
Source note	uspto-grants-2004_11