4-(2,6-Dimethylmorpholino)aniline → 6-Methoxy-8-(4-methyl-piperazin-1-yl)-4-oxo-4H-chromene-2-carboxylic acid [4-(2,6-dimethyl-morpholin-4-yl)-phenyl]-amide

Participants

Role	Name	HCID	Charge
Reactant	4-(2,6-Dimethylmorpholino)aniline	HCID 2794566	—
Reactant	6-Methoxy-8-(4-Methyl-piperazin-1-yl)-4-oxo-4H-chromene-2-carboxylic acid hydrochloride	HCID 69266755	—
Product	6-Methoxy-8-(4-methyl-piperazin-1-yl)-4-oxo-4H-chromene-2-carboxylic acid [4-(2,6-dimethyl-morpholin-4-yl)-phenyl]-amide	HCID 23533356	—

Reaction Steps

This compound was prepared from 6-methoxy-8-(4-Methyl-piperazin-1-yl)-4-oxo-4H-chromene-2-carboxylic acid hydrochloride (Reference Example 2) and commercially available 4-(2,6-dimethyl-morpholin-4-yl)-phenylamine (Maybridge) as prepared in Example 12, yielding a yellow solid. (70 mg=49%), LCMS-m/z=507.5.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06812225B2
Source dataset	uspto-grants-2004_11
ORD ID	ord-811b6107300443699c1127116ea3c9e5
Source note	uspto-grants-2004_11