HCID 23533336, compound → HCID 23533318, compound

HRID 2414523Notes

Reaction equation

HRID 2414523 reaction equation
Cl.[CH3:2][O:3][C:4]1[CH:5]=[C:6]2[C:11](=[C:12]([N:14]3[CH2:19][CH2:18][N:17]([CH3:20])[CH2:16][CH2:15]3)[CH:13]=1)[O:10][C:9]([C:21]([OH:23])=O)=[CH:8][C:7]2=[O:24].[N:25]1([C:31]([C:33]2[CH:38]=[CH:37][C:36]([NH:39]C(C3OC4C(C(=O)C=3)=CC=CC=4N3CCN(C)CC3)=O)=[CH:35]C=2)=O)[CH2:30][CH2:29][O:28][CH2:27][CH2:26]1>>[N:25]1([C:31]2[CH:35]=[C:36]([NH:39][C:21]([C:9]3[O:10][C:11]4[C:6]([C:7](=[O:24])[CH:8]=3)=[CH:5][C:4]([O:3][CH3:2])=[CH:13][C:12]=4[N:14]3[CH2:15][CH2:16][N:17]([CH3:20])[CH2:18][CH2:19]3)=[O:23])[CH:37]=[CH:38][CH:33]=2)[CH2:26][CH2:27][O:28][CH2:29][CH2:30]1

Participants

3

Reactant 2

HCID 23533336HCID 23533336, compoundHCID 692667556-Methoxy-8-(4-Methyl-piperazin-1-yl)-4-oxo-4H-chromene-2-carboxylic acid hydrochloride

Product 1

HCID 23533318HCID 23533318, compound

Procedure

This compound was prepared from 6-methoxy-8-(4-Methyl-piperazin-1-yl)-4-oxo-4H-chromene-2-carboxylic acid hydrochloride (Reference Example 2) and 3-morpholin-4-yl-phenylamine (Reference Example 18) as prepared in Example 12, yielding a yellow solid. (80 mg=60%), LCMS-m/z=479.5.

Workup

  1. customas prepared in Example 12
  2. customyielding a yellow solid

Sources & evidence

ORD record
ord-1730bf5fdb9240b8bac003e8d4470088
Source dataset
uspto-grants-2004_11
Patent number
US06812225B2

Reaction notes

Loading…