1-Hydroxybenzotriazole → HCID 22645338, compound

Participants

Reaction Steps

To a solution of 2-tert-butoxycarbonylamino-2-methylpropionic acid (2.03 g) and 1-hydroxybenzotriazole (1.35 g) in N,N-dimethylfolmamide (20 mL) was added 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (1.91 g) and the mixture was stirred overnight. The reaction mixture was partitioned between a mixture of ethyl acetate and n-hexane and water. The separated organic layer was washed in turn with water, a saturated sodium hydrogencarbonate in water and brine and dried over magnesium sulfate. The organic layer was evaporated under reduced pressure to give benzotriazol-1-yl 2-tert-butoxycarbonylamino-2-methylpropionate (2.94 g, 91.9%) as a solid.

Provenance & Evidence