HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → 355390-94-2
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Potassium bisulfate | HCID 516920 | — |
| Reactant | N-[(1,1-Dimethylethoxy)carbonyl]-N-2-propen-1-yl-beta-alanine ethyl ester | HCID 11265362 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 355390-94-2 | HCID 22645368 | 89.7% |
Reaction Steps
To a solution of ethyl N-(tert-butoxycarbonyl)-3-(2-propenylamino)propionate (1.0 g, 3.89 mmol) in methanol (10 mL) was added 1N aqueous LiOH solution (5.0 mL). After stirring overnight, the mixture was acidified to pH 2.5 with 20% aqueous KHSO4 solution, and extracted with ethyl acetate. The extract was dried over Na2SO4, and evaporated in vacuo to give N-(tert-butoxycarbonyl)-3-(2-propenylamino)propionic acid (0.8 g, 3.49 mmol, 89.7%) as a colourless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06812235B2 |
| Source dataset | uspto-grants-2004_11 |
| ORD ID | ord-f8813bcb4e07489684255476a42626d5 |
| Source note | uspto-grants-2004_11 |