Benzyl 4-Hydroxybenzoate → HCID 86587222, compound

Participants

Reaction Steps

To a mixture of KOH (0.74 g) in DMSO(15 ml) were added benzyl 4-hydroxybenzoate(1.5 g) and 1-bromo-4-methylpentane(2.78 ml), then the mixture was refluxed for an hour. Then the reaction mixture was partitioned between a mixture of ethyl acetate and water. The separated organic layer was washed in turn water, 20% aqueous sodium carbonate solution and brine, dried over magnesium sulfate and concentrated in vacuo. The residue was purified by a silica gel column chromatography eluting with a mixture of ethyl acetate and n-hexane (1:30) to give benzyl-4-isohexyloxybenzoate(1.18 g, 57.5%).

Provenance & Evidence